Relief for non-gastric, functional abdominal pain syndrome can often be achieved through treatments of the neurologic and musculoskeletal systems. Like non-cardiac chest pain, chronic pelvic, bladder and interstitial cystitis pain, non-gastric abdominal pain can have neurologic and musculoskeletal sources that contribute to the pain.

These musculoskeletal factors are not always obvious to the lay person or practicing physician. They may be present alone or in concert with other more traditional pain etiologies. Examples include Myofascial syndromes, spinal nerve irritations and facet syndromes, Iliopsoas muscle spasm and pubic ligament strain.