317 St. Francis Dr. #350
Greenville, SC 29601
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864.235.1834
Greenville, SC 29601
864.235.1834
By Matthew Terzella, MD
Board-Certified in Physical Medicine & Rehabilitation
Knee pain is one of the most common reasons patients come to Piedmont Physical Medicine & Rehabilitation. Whether caused by an injury, arthritis, or degenerative joint changes, knee pain often leads to inflammation, stiffness, and reduced mobility that can significantly affect daily life.
While medications are commonly used to manage knee pain, they typically focus on masking symptoms rather than addressing the underlying cause. At PPMR, we take a different approach. Our goal is to support your body’s natural ability to heal and repair itself using advanced regenerative and restorative therapies.
One of the most promising options for chronic knee pain is adipose-derived medicinal signaling cell therapy, which uses your own tissue to support joint health and function.
At PPMR, we use the BeautiFill® laser-assisted fat transfer system to harvest adipose (fat) tissue from your body in a gentle, controlled, closed-loop process. This system allows us to safely collect high-quality adipose tissue while preserving a very high percentage of healthy, viable cells.
The BeautiFill system:
Uses laser energy to gently loosen fat tissue
Minimizes trauma to surrounding tissue
Preserves over 95% cell viability
Allows for efficient processing and reinjection during the same procedure
Once harvested and processed, this adipose tissue contains medicinal signaling cells that can be injected into the knee joint. These cells help support the body’s natural repair response and provide volume and cushioning within the joint, which may be beneficial in degenerative conditions such as osteoarthritis.
Because the tissue comes from your own body, there are no artificial fillers, donor products, or foreign substances involved.
When we perform adipose-derived medicinal signaling cell therapy, we also incorporate platelet-rich plasma (PRP) to further support healing.
PRP is derived from your own blood through a simple blood draw. The blood is processed in a centrifuge to concentrate platelets, which are rich in natural growth factors and healing signals. PRP is then injected into the knee alongside the adipose tissue.
Together, adipose-derived cells and PRP work to:
Support the body’s repair processes
Reduce inflammation
Promote tissue health
Enhance overall treatment effectiveness
Many patients experience meaningful improvements in pain, mobility, and function following treatment. While individual results vary, improvements often begin to appear within three to four weeks, with continued progress over time.
At PPMR, we view this as part of a comprehensive care plan. We continue to work closely with patients through:
Follow-up visits
Nutritional guidance
Physical therapy or movement support when appropriate
This integrated approach helps maximize results over the following six months and beyond.
For patients with degenerative joint conditions, adipose-derived medicinal signaling cell therapy may offer an alternative to more invasive options such as surgery. By using the BeautiFill laser fat transfer system, we are able to support joint health using your body’s own natural resources.
This advanced approach to regenerative care represents a cutting-edge option in musculoskeletal medicine, particularly for patients seeking relief from chronic knee pain without artificial materials or long recovery times.
If you are experiencing chronic knee pain and want to explore whether BeautiFill laser fat transfer and regenerative therapies may be right for you, we’re here to help.