317 St. Francis Dr. #350
Greenville, SC 29601
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864.235.1834
Regenerative Prolotherapy Injections
A Non-Surgical Treatment to Strengthen Joints and Reduce Pain
What Is Prolotherapy?
Supporting your body’s natural healing response to relieve chronic pain
Prolotherapy is a regenerative injection treatment used to reduce chronic pain by helping strengthen weakened ligaments and tendons. When these tissues become injured or overstretched, they may cause joint instability — which can lead to ongoing pain. Prolotherapy works by gently stimulating your body’s natural healing response, encouraging new tissue growth so the joint can become stronger, more stable, and less painful over time.
At Piedmont Physical Medicine & Rehabilitation in Greenville, SC, our goal is always to address the underlying cause of pain, not just the symptoms, so you can get back to living more comfortably.
- Stimulates your body’s natural healing response
- Strengthens weakened ligaments and tendons
- Non-surgical treatment option
- Ideal for back pain, joint pain, tendon and ligament injuries
How It Works
Helps repair and re-grow injured ligaments and tendons
Medication made from natural compounds is injected into painful or weakened tissues
This stimulates your body’s natural wound-healing response
New tissue growth helps strengthen the area and support surrounding muscles and joints
Particularly helpful for chronic back pain, joint pain, sprains, and strains
- Can also benefit osteoarthritis, sports injuries, fibromyalgia, hypermobility, fascial injuries, and bursitis
What You’ll Experience
The first step is identifying the exact tissue that needs treatment using diagnostic musculoskeletal ultrasound
Treatment typically involves a short series of injections (often about 3 per area), spaced every 2–3 weeks
The solutions commonly used at PPMR include xylocaine and dextrose, which stimulate the body’s healing response
Some soreness is normal as healing begins — similar to how a scab forms over a skin wound
Healing continues over time as your body completes the regeneration process
Benefits You’ll Gain
A regenerative, non-surgical option for chronic muscle, tendon, ligament, and joint pain
Helps stabilize joints by strengthening supportive connective tissues
Supports natural healing rather than masking symptoms
Backed by years of clinical use and documented tissue re-growth
Provided by an experienced team who guides you through each step and evaluates whether the treatment is right for you
Could Fat Transfer Liposuction Therapy Help Your Chronic Pain?
BeautiFill™ uses your body’s fat cells to help support stability, cushioning, and long-term tissue healing.
